A novel nonsense ATP7A pathogenic variant in a family exhibiting a variable occipital horn syndrome phenotype

نویسندگان

  • Maria Teresa Bonati
  • Federico Verde
  • Uros Hladnik
  • Paola Cattelan
  • Luca Campana
  • Chiara Castronovo
  • Nicola Ticozzi
  • Luca Maderna
  • Claudia Colombrita
  • Sergio Papa
  • Paolo Banfi
  • Vincenzo Silani
چکیده

We report on a family with occipital horn syndrome (OHS) diagnosed in the proband's late fifties. A novel ATP7A pathogenic variant (c.4222A > T, p.(Lys1408*)), representing the first nonsense variant and the second late truncation causing OHS rather than classic Menkes disease, was found to segregate in the family. The predicted maintenance of transmembrane domains is consistent with a residual protein activity, which may explain the mild clinical presentation.

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Constitutive skipping of alternatively spliced exon 10 in the ATP7A gene abolishes Golgi localization of the menkes protein and produces the occipital horn syndrome.

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عنوان ژورنال:

دوره 13  شماره 

صفحات  -

تاریخ انتشار 2017